-主持或参加科研项目（课题）及人才计划项目情况
1. 福建省自然科学基金面上项目，2023J01128，可降解生物相容材料PHBV的微生物廉价发酵及其3HV组分提升机制研究，2023/01-2026/12，在研，主持。
2. 厦门自然科学基金项目，3502Z20227031，基于地中海富盐菌基因工程改造的胞内PHA颗粒粒径精确控制研究，2023/07-2025/06，在研，主持。
3. 国家自然科学基金青年项目，31700071，基于嗜盐古菌phaP/phaR重组表达的PHA颗粒粒径控制研究，2018/01-2020/12，结题，主持。
4. 福建省青年科技人才创新项目，2017J05052，海洋星虫纤溶酶的表达体系及溶栓机制研究，2017/04-2020/04，结题，主持。
5. 泉州市社发领域科技创新项目，2019N113S，基于全新生理靶点人工甜味剂干扰机体葡萄糖耐受的风险研究，2019/12-2022/12，结题，主持。
6. beat365 手机版官方网站科研启动费项目-引进人才类(NO. 15BS414)，海洋星虫纤溶酶的表达水平检测及其高效表达系统的建立，2015/11-2018/11，结题，主持。
7. 福建省海洋经济创新发展区域示范项目，2014FJPT08，台湾海峡海洋抗血栓纤溶酶基因库，2014/01-2016/12，结题，参加。
-代表性研究成果
第一或通讯作者：
(1) Sweet taste receptors play roles in artificial sweetener-induced enhanced urine output in mice. npj Sci Food, 2024. (一区，IF=7)
(2) Study on the production of high 3HV content PHBV via an open fermentation with waste silkworm excrement as the carbon source by the haloarchaeon Haloferax mediterranei. Frontiers in Microbiology, 2022. (TOP)
(3) Resistant starch (RS), a novel endogenous inert marker for detecting glucose absorption of small intestine with sweeteners administration in mice. Applied Biological Chemistry, 2022.
(4) Long term exposure to sucralose alters the sense of sweet tastants in an intestinal enteroendocrine cell model. International Food Research Journal, 2022.
(5) Production of Polyhydroxyalkanoates in Unsterilized Hyper-Saline Medium by Halophiles Using Waste Silkworm Excrement as Carbon Source. Molecules, 2021.
(6) 腺相关病毒介导的肝细胞癌靶向治疗策略，药学学报，2017。
(7) A novel DNA-binding protein, PhaR, plays a central role in the regulation of polyhydroxyalkanoate accumulation and granule formation in the haloarchaeon Haloferax mediterranei. Appl Environ Microbiol, 2015.
(8) Identification of the haloarchaeal phasin (PhaP) that functions in polyhydroxyalkanoate accumulation and granule formation in Haloferax mediterranei. Appl Environ Microbiol, 2012（至2022.9月被引>90次）
主要参与完成：
(1) Enoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei. Sci. Rep., 2016.
(2) Analysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei. Appl Environ Microbiol, 2014.
(3) Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins. Nat. Commun., 2015.
(4) A patatin-like protein associated with the polyhydroxyalkanoate (PHA) granules of Haloferax mediterranei acts as an efficient depolymerase in the degradation of native PHA. Appl Environ Microbiol, 2015.
(6) Cellular and organellar membrane-associated proteins in haloarchaea: perspectives on the physiological significance and biotechnological applications. Sci China Life Sci, 2012.
(7) Proteome reference map of Haloarcula hispanica and comparative proteomic and transcriptomic analysis of polyhydroxyalkanoate biosynthesis under genetic and environmental perturbations. J Proteome Res, 2013.
(8) Multiple propionyl coenzyme A-supplying pathways for production of the bioplastic poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Haloferax mediterranei. Appl Environ Microbiol, 2013.
